1 Title : Topological basis of epileptogenesis in a model of severe cortical trauma

Title: Topological basis of epileptogenesis in a model of severe cortical trauma 2 Authors: Vladislav Volman, Terrence J. Sejnowski, Maxim Bazhenov 3 4 1. Howard Hughes Medical Institute, Computational Neurobiology Laboratory, The Salk 5 Institute for Biological Studies, La Jolla, CA 92037, USA 6 2. Center for Theoretical Biological Physics, University of California San Diego, La Jolla, 7 CA 92093, USA 8 3. Division of Biological Sciences, University of California, San Diego, La Jolla, CA 9 92093, USA 10 4. Department of Cell Biology and Neuroscience, University of California, Riverside, 11 Riverside, CA 92521, USA 12 13 Running title: Epileptogenesis in severely traumatized cortex 14 15 Corresponding author: 16 Dr. Maxim Bazhenov 17 Department of Cell Biology and Neuroscience, University of California, Riverside, 18 Riverside, CA 92521, USA. 19 Email: [email protected] 20 21 22 23 24 25 26 Articles in PresS. J Neurophysiol (July 20, 2011). doi:10.1152/jn.00458.2011